2023 Meeting

Michigan Union, University of Michigan

Ann Arbor, Michigan
May 4-5, 2023
Meeting Booklet

Thursday, May 4th

Check in, Coffee, Poster Setup, and Sponsor Booth Setup, 10:00 AM

Welcome, 11:00 AM
Yoichi Osawa, Ph.D., Dept. of Pharmacology, University of Michigan, Ann Arbor, MI

Investigations of P450 MBI: The Value of Understanding Mechanisms Beyond Kinact, 11:10 AM
Larry Wienkers, Ph.D., Wienkers Consulting, LLC, Seattle, WA

Extracellular Vesicle (EV)-Based Liquid Biopsy in DMPK: Where Are We Now and Where Are We Going?, 11:50 AM
David Rodrigues, Ph.D., Senior Scientific Director, Head of Drug Transporter & ADME Biomarker Sciences, PDM Medicine Design, Pfizer, Groton, CT

Lunch, Students and Postdocs Network with Industry Scientists, View Posters, and Visit Sponsor Booths, 12:30 PM

The Cancer Target CD73 Regulates Hepatocyte Function and is Necessary for Long-term Liver Homeostasis, 2:00 PM
Natasha Snider, Ph.D., Associate Professor, Dept. of Cell Biology and Physiology, School of Medicine, University of North Carolina, Chapel Hill, NC

DMET Applications of a Kidney Microphysiological System, 2:40 PM
Edward Kelly, Ph.D., Associate Professor, Dept. of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA

Break, 3:20 PM

Empagliflozin: Identification of ADME-related Differences in Human vs. Toxicology Species, 3:40 PM
Mitchell Taub, Ph.D., Director of Non-Clinical DMPK, Boehringer Ingelheim Pharmaceuticals, CT

ADME Tactics in the Discovery & Development of the Orally Active SARS-COV-2 Inhibitor Nirmatrelvir, 4:20 PM
Amit Kalgutkar, Ph.D., Senior Research Fellow, DMPK Lead, Rare Disease and Antivirals Therapeutics, Pfizer, Cambridge, MA

Poster Session (Author Available), Sponsor Booths, and Mixer, 5:00 PM
Authors at odd numbered posters (5:00-6:00 PM)
Authors at even numbered posters (6:00-7:00 PM)

Dinner, 7:30 PM

Friday, May 5th

GLDMDG Business Meeting, 7:30 AM

Continental Breakfast, Poster Viewing and Sponsor Booth Setup, 7:30 AM

A League of Their Own: Translational ADME for PROTACs, 9:00 AM
Marjoleen Nijsen, Ph.D., Vice President, DMPK, AbbVie, Chicago, IL

Understanding the Disconnect of In Vitro CYP3A4 Time Dependent Inhibition, 9:40 AM
Luc Rougee, Ph.D., Senior Advisor, Drug Disposition, Eli Lilly, Indianapolis, IN

Break, 0:20 AM

Multi-omic Discovery Used Drug Perturbation in African American Hepatocytes, 10:40 AM
Minoli Perera, Pharm.D., Ph.D., Associate Professor, Dept. of Pharmacology, Northwestern University, Chicago, IL

Multi-omic Analysis of Drug Metabolism in African Americans by Leveraging Primary Human Hepatocytes to Capture Interindividual Variability, 11:20 AM
Carolina Lee Clark, M.S., Northwestern University
Student Abstract Award Winner

What’s All the HUpLA? Proof of Concept for a Novel Assay for Obtaining Uptake, Efflux, and Intrinsic Metabolic Clearance Based on the Extended Clearance Concept, 11:35 AM
Julia A. Schulz Pauly, Ph.D., Quantitative, Translational & ADME Sciences, AbbVie.
Postdoc Abstract Award Winner.

Closing Remarks, 11:50 AM